Low-fluence rate, long duration photodynamic therapy in glioma mouse model using organic light emitting diode (OLED)

Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer...

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Published inPhotodiagnosis and photodynamic therapy Vol. 12; no. 3; pp. 504 - 510
Main Authors Guo, Han-Wen, Lin, Liang-Ting, Chen, Po-Hsiung, Ho, Meng-Huan, Huang, Wan-Ting, Lee, Yi-Jang, Chiou, Shih-Hwa, Hsieh, Yei-San, Dong, Chen-Yuan, Wang, Hsing-Wen
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.09.2015
Subjects
5-Aminolevulinic acid (ALA)
Aminolevulinic Acid - pharmacology
Animals
Disease Models, Animal
Glioblastoma - drug therapy
Gliomas
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Metronomic photodynamic therapy (mPDT)
Mice
Mice, Nude
Organic light emitting diode (OLED)
Photochemotherapy - methods
Photosensitizing Agents - pharmacology
Pilot Projects
Protoporphyrins
Survival Analysis
Time Factors
5-Aminolevulinic acid (ALA)
Gliomas
Metronomic photodynamic therapy (mPDT)
Organic light emitting diode (OLED)
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Summary:Highlights • We demonstrated the feasibility of low-fluence rate and long duration OLED-PDT in glioma mouse model. • Tumor severity shows statistically significant correlation with survival days. • mPDT in glioma mouse model is promising with a longer survival time. • Maintenance of photosensitizer fluorescence and oxygenation is critical for PDT.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2015.04.007