Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

• Published in: Cytokine (Philadelphia, Pa.) Vol. 41; no. 2; pp. 92 - 104
• Main Authors: Shen, Fang, Gaffen, Sarah L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2008
• Subjects: Act1; Animals; Antibodies - therapeutic use; Arthritis, Rheumatoid - drug therapy; Bone Remodeling - physiology; CCAAT-Enhancer-Binding Proteins - physiology; Cytokines - immunology; Humans; Inflammation Mediators - physiology; Interleukin-17; Interleukin-6 - physiology; NF-kappa B - physiology; Protein Structure, Tertiary; Receptor; Receptors, Interleukin-17 - physiology; Receptors, Interleukin-17 - therapeutic use; Signal transduction; Signal Transduction - physiology; Structure-Activity Relationship; Synergy; T-Lymphocytes, Helper-Inducer - physiology; Transcription Factors - physiology; Act1; Signal transduction; Synergy; Interleukin-17; Receptor

IL-17 is the defining cytokine of a newly-described “Th17” population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the most recent class of cytokines and receptors to be described, and until recently very little was known about its fun...