Structure–function relationships in the IL-17 receptor: Implications for signal transduction and therapy

IL-17 is the defining cytokine of a newly-described “Th17” population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the most recent class of cytokines and receptors to be described, and until recently very little was known about its fun...

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Bibliographic Details
Published inCytokine (Philadelphia, Pa.) Vol. 41; no. 2; pp. 92 - 104
Main Authors Shen, Fang, Gaffen, Sarah L.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2008
Subjects
Act1
Animals
Antibodies - therapeutic use
Arthritis, Rheumatoid - drug therapy
Bone Remodeling - physiology
CCAAT-Enhancer-Binding Proteins - physiology
Cytokines - immunology
Humans
Inflammation Mediators - physiology
Interleukin-17
Interleukin-6 - physiology
NF-kappa B - physiology
Protein Structure, Tertiary
Receptor
Receptors, Interleukin-17 - physiology
Receptors, Interleukin-17 - therapeutic use
Signal transduction
Signal Transduction - physiology
Structure-Activity Relationship
Synergy
T-Lymphocytes, Helper-Inducer - physiology
Transcription Factors - physiology
Act1
Signal transduction
Synergy
Interleukin-17
Receptor
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Summary:IL-17 is the defining cytokine of a newly-described “Th17” population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the most recent class of cytokines and receptors to be described, and until recently very little was known about its function or molecular biology. However, in the last year important new insights into the composition and dynamics of the receptor complex and mechanisms of downstream signal transduction have been made, which will be reviewed here.
Bibliography:ObjectType-Article-2
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ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2007.11.013