Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: A systematic review
The dual burden of tuberculosis (TB) and diabetes mellitus (DM) has become a major global public health concern. There is mounting evidence from different countries on the burden of TB and DM comorbidity. The objective of this systematic review was to summarize the existing evidence on prevalence an...
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Published in | PloS one Vol. 12; no. 4; p. e0175925 |
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Main Authors | , , |
Format | Journal Article |
Language | English Norwegian |
Published |
United States
Public Library of Science
2017
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
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Summary: | The dual burden of tuberculosis (TB) and diabetes mellitus (DM) has become a major global public health concern. There is mounting evidence from different countries on the burden of TB and DM comorbidity. The objective of this systematic review was to summarize the existing evidence on prevalence and associated/risk factors of TBDM comorbidity at global and regional levels.
Ovid Medline, Embase, Global health, Cochrane library, Web of science and Scopus Elsevier databases were searched to identify eligible articles for the systematic review. Data were extracted using standardized excel form and pilot tested. Median with interquartile range (IQR) was used to estimate prevalence of TBDM comorbidity. Associated/risk factors that were identified from individual studies were thematically analyzed and described.
The prevalence of DM among TB patients ranged from 1.9% to 45%. The overall median global prevalence was 16% (IQR 9.0%-25.3%) Similarly, the prevalence of TB among DM patients ranged from 0.38% to 14% and the overall median global prevalence was 4.1% (IQR 1.8%-6.2%). The highest prevalence of DM among TB patients is observed in the studied countries of Asia, North America and Oceania. On the contrary, the prevalence of TB among DM patients is low globally, but relatively higher in the studied countries of Asia and the African continents. Sex, older age, urban residence, tobacco smoking, sedentary lifestyle, poor glycemic control, having family history of DM and TB illness were among the variables identified as associated/risk factors for TBDM comorbidity.
This systematic review revealed that there is a high burden of DM among TB patients at global level. On the contrary, the global prevalence of TB among DM patients is low. Assessing the magnitude and risk/associated factors of TBDM comorbidity at country/local level is crucial before making decisions to undertake TBDM integrated services. |
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Bibliography: | SourceType-Scholarly Journals-1 ObjectType-Feature-4 ObjectType-Undefined-1 content type line 23 ObjectType-Review-2 ObjectType-Article-3 NFR/NFR project# 234506 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: MHW GAB SAY.Formal analysis: MHW GAB SAY.Investigation: MHW.Methodology: MHW GAB SAY.Supervision: GAB SAY.Validation: MHW SAY.Writing – original draft: MHW.Writing – review & editing: MHW GAB SAY. |
ISSN: | 1932-6203 1932-6203 |
DOI: | 10.1371/journal.pone.0175925 |