A causal role for the right angular gyrus in self-location mediated perspective taking

• Published in: Scientific reports Vol. 10; no. 1; p. 19229
• Main Authors: de Boer, D. M. L., Johnston, P. J., Kerr, G., Meinzer, M., Cleeremans, A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.11.2020; Nature Publishing Group
• Subjects: 631/378; 631/477; Adolescent; Adult; Attention - physiology; Body Image; Brain injury; Double-Blind Method; Dreams; Female; Humanities and Social Sciences; Humans; Illusions - physiology; Male; Mental disorders; multidisciplinary; Nervous system; Parietal Lobe - physiology; Psychosis; Rehabilitation; Science; Science (multidisciplinary); Self Concept; Transcranial Direct Current Stimulation; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-76235-7

Recent theories suggest that self-consciousness, in its most elementary form, is functionally disconnected from the phenomenal body. Patients with psychosis frequently misattribute their thoughts and actions to external sources; and in certain out-of-body experiences, lucid states, and dreams body-ownership is absent but self-identification is preserved. To explain these unusual experiences, we hypothesized that self-identification depends on inferring self-location at the right angular gyrus (i.e., perspective-taking). This process relates to the discrimination of self-produced signals (endogenous attention) from environmental stimulation (exogenous attention). Therefore, when this mechanism fails, this causes altered sensations and perceptions. We combined a Full-body Illusion paradigm with brain stimulation (HD-tDCS) and found a clear causal association between right angular gyrus activation and alterations in self-location (perspective-taking). Anodal versus sham HD-tDCS resulted in: a more profound out-of-body shift (with reduced sense of agency); and a weakened ability to discriminate self from other perspectives. We conclude that self-identification is mediated in the brain by inferring self-location (i.e., perspective-taking). Self-identification can be decoupled from the bodily self, explaining phenomena associated with disembodiment. These findings present novel insights into the relationship between mind and body, and may offer important future directions for treating psychosis symptoms and rehabilitation programs to aid in the recovery from a nervous system injury. The brain’s ability to locate itself might be the key mechanism for self-identification and distinguishing self from other signals (i.e., perspective-taking).