Ultrafast Harmonic Coherent Compound (UHCC) Imaging for High Frame Rate Echocardiography and Shear-Wave Elastography

• Published in: IEEE transactions on ultrasonics, ferroelectrics, and frequency control Vol. 63; no. 3; pp. 420 - 431
• Main Authors: Correia, Mafalda, Provost, Jean, Chatelin, Simon, Villemain, Olivier, Tanter, Mickael, Pernot, Mathieu
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.03.2016; The Institute of Electrical and Electronics Engineers, Inc. (IEEE); Institute of Electrical and Electronics Engineers
• Subjects: Acoustics; Animals; Bioengineering; Biomechanics; Cardiology and cardiovascular system; coherent compounding; Echocardiography - methods; Elasticity Imaging Techniques - methods; Frequency control; Harmonic analysis; Heart - diagnostic imaging; Human health and pathology; Humans; Image Processing, Computer-Assisted - methods; Imaging; Life Sciences; Meat; Mechanics; Models, Biological; Phantoms, Imaging; Physics; Power harmonic filters; Probes; Shear wave elastography; Signal-To-Noise Ratio; Swine; ultrafast imaging; Ultrasonic imaging; pulse-inversion (PI) harmonic imaging; Cardiac stiffness; shear-wave elastography (SWE); ultrafast imaging; coherent compounding
• ISSN: 0885-3010; 1525-8955
• DOI: 10.1109/TUFFC.2016.2530408

Transthoracic shear-wave elastography (SWE) of the myocardium remains very challenging due to the poor quality of transthoracic ultrafast imaging and the presence of clutter noise, jitter, phase aberration, and ultrasound reverberation. Several approaches, such as diverging-wave coherent compounding or focused harmonic imaging, have been proposed to improve the imaging quality. In this study, we introduce ultrafast harmonic coherent compounding (UHCC), in which pulse-inverted diverging waves are emitted and coherently compounded, and show that such an approach can be used to enhance both SWE and high frame rate (FR) B-mode Imaging. UHCC SWE was first tested in phantoms containing an aberrating layer and was compared against pulse-inversion harmonic imaging and against ultrafast coherent compounding (UCC) imaging at the fundamental frequency. In vivo feasibility of the technique was then evaluated in six healthy volunteers by measuring myocardial stiffness during diastole in transthoracic imaging. We also demonstrated that improvements in imaging quality could be achieved using UHCC B-mode imaging in healthy volunteers. The quality of transthoracic images of the heart was found to be improved with the number of pulse-inverted diverging waves with a reduction of the imaging mean clutter level up to 13.8 dB when compared against UCC at the fundamental frequency. These results demonstrated that UHCC B-mode imaging is promising for imaging deep tissues exposed to aberration sources with a high FR.