Data characterizing the biophysical and nitric oxide release properties of the tDodSNO – Styrene maleic anhydride nanoparticle SMA-tDodSNO

Nitric oxide (NO) donor drugs have a range of clinical applications, and are also being developed as therapeutics for the potential treatment of multiple diseases. This article presents data describing the synthesis and characterisation of a novel NO releasing nanoparticle formed by encapsulation of...

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Bibliographic Details
Published inData in brief Vol. 21; pp. 1771 - 1775
Main Authors Alimoradi, Houman, Barzegar-Fallah, Anita, Sammut, Ivan A., Greish, Khaled, Giles, Gregory I.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.12.2018
Elsevier
Subjects
composite polymers
encapsulation
maleic acid
maleic anhydrides
medicinal properties
nitric oxide
Pharmacology, Toxicology and Pharmaceutical Science
styrene
therapeutics
vasodilation
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Summary:Nitric oxide (NO) donor drugs have a range of clinical applications, and are also being developed as therapeutics for the potential treatment of multiple diseases. This article presents data describing the synthesis and characterisation of a novel NO releasing nanoparticle formed by encapsulation of the NO donor tDodSNO into a co-polymer of styrene and maleic acid (SMA) to afford SMA-tDodSNO. The pharmacological activity of SMA-tDodSNO is discussed in our accompanying manuscript “Encapsulation of tDodSNO generates a photoactivated nitric oxide releasing nanoparticle for localized control of vasodilation and vascular hyperpermeability”. (Alimoradio et al. [1]).
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ISSN:2352-3409
2352-3409
DOI:10.1016/j.dib.2018.10.149