CSF-PR 2.0: An Interactive Literature Guide to Quantitative Cerebrospinal Fluid Mass Spectrometry Data from Neurodegenerative Disorders

• Published in: Molecular & cellular proteomics Vol. 16; no. 2; pp. 300 - 309
• Main Authors: Guldbrandsen, Astrid, Farag, Yehia, Kroksveen, Ann Cathrine, Oveland, Eystein, Lereim, Ragnhild R., Opsahl, Jill A., Myhr, Kjell-Morten, Berven, Frode S., Barsnes, Harald
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2017; American Society for Biochemistry and Molecular Biology; The American Society for Biochemistry and Molecular Biology
• Subjects: Alzheimer's disease; Cerebrospinal fluid; Cerebrospinal Fluid Proteins - analysis; Databases, Protein; Datasets as Topic; Filtration; Humans; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Movement disorders; Multiple sclerosis; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Parkinson's disease; Proteins; Proteomics; Proteomics - methods; Scientific imaging; Scientific papers; Spectroscopy; Technological Innovation and Resources; Web Browser
• ISSN: 1535-9476; 1535-9484
• DOI: 10.1074/mcp.O116.064477

The rapidly growing number of biomedical studies supported by mass spectrometry based quantitative proteomics data has made it increasingly difficult to obtain an overview of the current status of the research field. A better way of organizing the biomedical proteomics information from these studies and making it available to the research community is therefore called for. In the presented work, we have investigated scientific publications describing the analysis of the cerebrospinal fluid proteome in relation to multiple sclerosis, Parkinson's disease and Alzheimer's disease. Based on a detailed set of filtering criteria we extracted 85 data sets containing quantitative information for close to 2000 proteins. This information was made available in CSF-PR 2.0 (http://probe.uib.no/csf-pr-2.0), which includes novel approaches for filtering, visualizing and comparing quantitative proteomics information in an interactive and user-friendly environment. CSF-PR 2.0 will be an invaluable resource for anyone interested in quantitative proteomics on cerebrospinal fluid.