Preparation of Swellable Hydrogel‐Containing Colloidosomes from Aqueous Two‐Phase Pickering Emulsion Droplets

• Published in: Angewandte Chemie International Edition Vol. 57; no. 26; pp. 7780 - 7784
• Main Authors: Douliez, Jean‐Paul, Martin, Nicolas, Beneyton, Thomas, Eloi, Jean‐Charles, Chapel, Jean‐Paul, Navailles, Laurence, Baret, Jean‐Christophe, Mann, Stephen, Béven, Laure
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 25.06.2018; Wiley-VCH Verlag
• Edition: International ed. in English
• Subjects: aqueous two-phase systems; Beads; Carbodiimide; colloidosomes; Colloids; Condensed Matter; Crosslinking; Dextran; Droplets; Emulsions; encapsulation; Fabrication; Fluorescence; Hydrogels; Latex; Latex beads; Microencapsulation; Molecular chains; Physics; Polyacrylic acid; Polystyrene; Polystyrene resins; sequestration; water-in-water emulsions; aqueous two-phase systems; encapsulation; water-in-water emulsions; colloidosomes; sequestration; water-in-water emultions; Aqueous two-phase systems; Sequestration
• ISSN: 1433-7851; 1521-3773; 1521-3773
• DOI: 10.1002/anie.201802929

The fabrication of stable colloidosomes derived from water‐in‐water Pickering‐like emulsions are described that were produced by addition of fluorescent amine‐modified polystyrene latex beads to an aqueous two‐phase system consisting of dextran‐enriched droplets dispersed in a PEG‐enriched continuous phase. Addition of polyacrylic acid followed by carbodiimide‐induced crosslinking with dextran produces hydrogelled droplets capable of reversible swelling and selective molecular uptake and exclusion. Colloidosomes produced specifically in all‐water systems could offer new opportunities in microencapsulation and the bottom‐up construction of synthetic protocells. Ready to load: Hybrid hydrogel‐colloidosomes capable of swelling and spontaneous uptake of payloads have been fabricated from water‐in‐water emulsions.