Cardiovascular Metabolomics

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from...

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Bibliographic Details
Published inCirculation research Vol. 122; no. 9; pp. 1238 - 1258
Main Authors McGarrah, Robert W., Crown, Scott B., Zhang, Guo-Fang, Shah, Svati H., Newgard, Christopher B.
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 27.04.2018
Lippincott Williams & Wilkins Ovid Technologies
Subjects
Animals
Biomarkers
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - metabolism
Chromatography, Liquid
Coronary artery disease
Forecasting
Health risk assessment
Heart diseases
Humans
Ischemia
Isotopes
Isotopes - analysis
Mass Spectrometry
Metabolic flux
Metabolism
Metabolomics
Metabolomics - methods
Mice
Myocardium - metabolism
Nuclear Magnetic Resonance, Biomolecular
Proteome
Research Design
Risk Assessment
Specimen Handling
heart failure
ketone bodies
metabolism
cardiovascular diseases
amino acids
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Summary:Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics, one of the newer omics technologies, has emerged as a powerful tool for defining changes in both global and cardiac-specific metabolism that occur across a spectrum of cardiovascular disease states. Findings from metabolomics studies have contributed to better understanding of the metabolic changes that occur in heart failure and ischemic heart disease and have identified new cardiovascular disease biomarkers. As technologies advance, the metabolomics field continues to evolve rapidly. In this review, we will discuss the current state of metabolomics technologies, including consideration of various metabolomics platforms and elements of study design; the emerging utility of stable isotopes for metabolic flux studies; and the use of metabolomics to better understand specific cardiovascular diseases, with an emphasis on recent advances in the field.
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Authors contributed equally
ISSN:0009-7330
1524-4571
1524-4571
DOI:10.1161/CIRCRESAHA.117.311002