Indonesian Medicinal Plants. VIII. Chemical Structures of Three New Triterpenoids, Bruceajavanin A, Dihydrobruceajavanin A, and Bruceajavanin B, and a New Alkaloidal Glycoside, Bruceacanthinoside, from the Stems of Brucea javanica (Simaroubaceae)

• Published in: Chemical & pharmaceutical bulletin Vol. 42; no. 7; pp. 1416 - 1421
• Main Authors: KITAGAWA, Isao, MAHMUD, Taifo, SIMANJUNTAK, Partomuan, HORI, Kazuyuki, UJI, Tahan, SHIBUYA, Hirotaka
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1994; Maruzen; Japan Science and Technology Agency
• Subjects: Animals; Antimalarials - isolation & purification; Antimalarials - pharmacology; apotirucallane triterpenoid; Biological and medical sciences; Brucea javanica; General pharmacology; Humans; Indonesia; Indonesian medicinal plant; Magnetic Resonance Spectroscopy; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal - chemistry; Plasmodium falciparum - drug effects; Simaroubaceae; Triterpenes - isolation & purification; Triterpenes - pharmacology; β-carboline alkaloidal glycoside; Asia; Indonesia; Steroid; Antimalarial; Pharmacognosy; Tetracyclic compound; Stem; Medicinal plant; Simaroubaceae; Alkaloid; Terpene; Dicotyledones; Angiospermae; Parasiticid; Plant origin; Isolation; Spermatophyta; Structural analysis
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.42.1416

Three new apotirucallane-type triterpenoids named bruceajavanin A (1) dihydrobruceajavanin A (2), and bruceajavanin B (3), and a novel β-carboline alkaloidal glycoside named bruceacanthinoside (4) were isolated from the stems of Brucea javanica (Simaroubaceae), a traditional medicine used to treat malaria in the Bengkulu area, Sumatra, Indonesia. Their chemical structures have been elucidated on the bases of their chemical and physicochemical properties. Bruceajavanin A (1), dihydrobruceajavanin A (2) and bruceacanthinoside (4) were shown to inhibit growth of the cultured malarial parasite Plasmodium falciparum K1 of a chloroquine-resistant strain.