A tool for scoring of acneiform skin eruptions induced by EGF receptor inhibition

• Published in: Experimental dermatology Vol. 17; no. 9; pp. 790 - 792
• Main Authors: Wollenberg, Andreas, Moosmann, Nicolas, Klein, Elisabeth, Katzer, Kerstin
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2008; Blackwell
• Subjects: Acneiform Eruptions - chemically induced; Biological and medical sciences; Dermatology; Humans; Medical sciences; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Severity of Illness Index; Epidermal growth factor; Dermatology; Inhibitor; Skin; Inhibition; Epidermal growth factor receptor; Tool; Biological receptor
• ISSN: 0906-6705; 1600-0625
• DOI: 10.1111/j.1600-0625.2008.00715.x

:  Acneiform skin eruptions are the most common side effect of epidermal growth factor receptor (EGFR) inhibitors. The National Cancer Institute Common Toxicity Criteria allow for quick severity estimation of a patient, but are not suitable for monitoring the severity of the skin lesions over time, as needed for treatment studies. Here we present our scoring tool for acneiform skin eruptions, which is calculated from body involvement, facial involvement and clinical grading of the skin items erythema, papulation, pustulation and scaling/crusts. The final score is a number between 0 and 100.