Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study

• Published in: International journal of endocrinology Vol. 2018; no. 2018; pp. 1 - 10
• Main Authors: Bautista-Charry, Alejandro Antonio, Alzate, Héctor Fabio Sandoval, Acosta, Luis Miguel Maldonado, Sanchez, Elizabeth, Ruíz-Parra, Ariel Iván, Caminos, Jorge E., Parra-Pineda, Mario Orlando, Garzón-Olivares, Carmen Doris, Díaz-Cruz, Luz Amparo, Sánchez, Estefania Pulido, Jaimes, Silvia Alejandra Blanco, Darghan, Aquiles Enrique, Garcés, María Fernanda, Poveda, Natalia Elvira, Müller, Edith Ángel
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Body mass index; Cholesterol; Endocrinology; Fetuses; Glucose; Health aspects; Insulin resistance; Lipoproteins; Longitudinal studies; Low density lipoproteins; Menstruation; Metabolism; Physiology; Preeclampsia; Pregnancy; Pregnant women; Triglycerides; Women; Womens health; Colombia; United States > US; Colorado
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2018/8956404

Metabolic changes have been correlated with adverse pregnancy outcomes. The aim of the present study is to determine the TyG and TG/HDL-c indices in a cohort of healthy pregnant (n=142), preeclamptic (n=18), and healthy nonpregnant women (n=56). Preeclamptic women were selected from the same cohort. Pregnant women were followed during three periods of pregnancy and postpartum. The results showed a significant increase in the values of TyG and TG/HDL-c (p<0.01) as pregnancy progresses, without significant differences between healthy and preeclamptic women. TyG and TG/HDL-c indices are significantly low in nonpregnant and three months’ postpartum women when compared with each gestational period studied. TyG and TG/HDL-c indices are positively correlated with HOMA-IR in the early and middle pregnancy (p<0.05). Multiple linear regression using the TyG and TG/HDL-c indices as dependent variables showed that TyG index was significantly associated with HOMA-IR, gestational age, HDL-c, TC, LDL, fasting insulin, and mean BP (p<0.001); meanwhile, TG/HDL-c index was only associated with HOMA-IR (p<0.0242) and gestational age (p<0.001). In conclusion, the TyG and TG/HDL-c indices could be useful in monitoring insulin resistance during pregnancy.