Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy

Sarcoma is comprised of a heterogeneous group of tumors originating from the mesenchyme. Sarcoma is also the first tumor that responded to immunotherapeutic agents often termed as “Coley’s toxins.” However, immunotherapy is yet to establish its presence in sarcomas. Complex interactions between tumo...

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Published inComplexity (New York, N.Y.) Vol. 2018; no. 2018; pp. 1 - 10
Main Authors Raj, Shailaja, Triozzi, Pierre L., Miller, Lance D.
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2018
Hindawi
Hindawi Limited
Wiley
Subjects
B cells
Cancer therapies
Chemotherapy
Cytokines
Dendritic cells
Development and progression
Gene therapy
Genetic engineering
Immunotherapy
Kinases
Lymphocytes
Macrophages
Medical prognosis
Medical research
Melanoma
Mesenchyme
Metastasis
Mutation
Oncology
Prognosis
Proteins
Review
Sarcoma
Soft tissue sarcoma
Tissues
Tumors
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Summary:Sarcoma is comprised of a heterogeneous group of tumors originating from the mesenchyme. Sarcoma is also the first tumor that responded to immunotherapeutic agents often termed as “Coley’s toxins.” However, immunotherapy is yet to establish its presence in sarcomas. Complex interactions between tumor and immune cells in the tumor microenvironment play a crucial role in response to immunotherapy. There is a dynamic equilibrium created by the immune cells infiltrating the tumor, and this forms the basis of tumor evasion. Manipulating the intratumoral microenvironment will help overcome tumor evasion.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Academic Editor: Eugenie S. Kleinerman
ISSN:1076-2787
1357-714X
1099-0526
1369-1643
DOI:10.1155/2018/9305294