Spray Drying of Griseofulvin Solution Forming Its Solvate

A spray drying process was introduced into our method of particle size reduction by "solvation and desolvation" for the purpose of producing spherical particles with a large effective surface area. By solvate formation and successive desolvation in a single process of spray drying, prepara...

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Bibliographic Details
Published in	Chemical & pharmaceutical bulletin Vol. 36; no. 6; pp. 2193 - 2196
Main Authors	TSUDA, YASUYUKI, SUZUKI, ETSUKO, ISHIDA, MARIKO, SEKIGUCHI, KEIJI
Format	Journal Article
Language	English
Published	Tokyo The Pharmaceutical Society of Japan 1988 公益社団法人日本薬学会 Maruzen Japan Science and Technology Agency
Subjects	Chemistry Chemistry, Pharmaceutical chloroformate Colloidal state and disperse state Exact sciences and technology General and physical chemistry griseofulvin Griseofulvin - analysis particle size reduction Physical and chemical studies. Granulometry. Electrokinetic phenomena Solutions solvate formation spray drying Particle size Thermogravimetry Spherical particle Particle suspension Surface area Experimental study X ray diffraction Powder
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ISSN	0009-2363 1347-5223
DOI	10.1248/cpb.36.2193

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Summary:	A spray drying process was introduced into our method of particle size reduction by "solvation and desolvation" for the purpose of producing spherical particles with a large effective surface area. By solvate formation and successive desolvation in a single process of spray drying, preparation of spherical particles, which consist of primary fines, was achieved.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.36.2193