Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI

• Published in: Magnetic resonance in medicine Vol. 65; no. 3; pp. 627 - 637
• Main Authors: Balu, Niranjan, Yarnykh, Vasily L., Chu, Baocheng, Wang, Jinnan, Hatsukami, Thomas, Yuan, Chun
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.03.2011
• Subjects: 3D-MERGE; Aged; Algorithms; Anisotropy; approach to spoiled steady state; carotid atherosclerotic plaque; Carotid Stenosis - pathology; diffusion preparation; Female; Humans; Image Enhancement - methods; Image Interpretation, Computer-Assisted - methods; Imaging, Three-Dimensional - methods; Magnetic Resonance Angiography - methods; Male; MSDE; Reproducibility of Results; Sensitivity and Specificity; snapshot FLASH; SPACE; three dimensional black-blood; vessel wall imaging
• ISSN: 0740-3194; 1522-2594; 1522-2594
• DOI: 10.1002/mrm.22642

Black‐blood MRI is a promising tool for carotid atherosclerotic plaque burden assessment and compositional analysis. However, current sequences are limited by large slice thickness. Accuracy of measurement can be improved by moving to isotropic imaging but can be challenging for patient compliance due to long scan times. We present a fast isotropic high spatial resolution (0.7 × 0.7 × 0.7 mm3) three‐dimensional black‐blood sequence (3D‐MERGE) covering the entire cervical carotid arteries within 2 min thus ensuring patient compliance and diagnostic image quality. The sequence is optimized for vessel wall imaging of the carotid bifurcation based on its signal properties. The optimized sequence is validated on patients with significant carotid plaque. Quantitative plaque morphology measurements and signal‐to‐noise ratio measures show that 3D‐MERGE provides good blood suppression and comparable plaque burden measurements to existing MRI protocols. 3D‐MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.