Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effect...

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Published inPharmaceutics Vol. 14; no. 10; p. 2244
Main Authors Rezaei, Zahra, Yilmaz-Aykut, Dilara, Tourk, Fatima Mumtaza, Bassous, Nicole, Barroso-Zuppa, Margot, Shawl, Asif Iqbal, Ashraf, Syed Salman, Avci, Huseyin, Hassan, Shabir
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.10.2022
MDPI
Subjects
Antimitotic agents
Antineoplastic agents
Arthritis
Biodegradable materials
biomaterials
Biomedical materials
Cancer therapies
Chemical properties
Colloids
Cytokines
Diabetes
Dosage and administration
Drug delivery systems
Drugs
Fibroblasts
Foreign bodies
foreign body response
Genotype & phenotype
Glucose
Growth factors
Health aspects
Hydrogels
immune modulation
Immunotherapy
Inflammation
Insulin
Nanoparticles
Osteoarthritis
Pharmaceutical research
Regenerative medicine
Review
Tissue engineering
Transplants & implants
Vehicles
United Arab Emirates
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Summary:Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.
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These authors contributed equally to this work.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14102244