The microRNA-127-3p directly targeting Vamp2 in C2C12 myoblasts

MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well el...

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Bibliographic Details
Published inAnimal cells and systems Vol. 22; no. 5; pp. 299 - 304
Main Authors Li, Jie, Wang, Gaofu, Jiang, Jing, Fu, Lin, Zhou, Peng, Ren, Hangxing
Format Journal Article
LanguageEnglish
Published Korea (South) Taylor & Francis 03.09.2018
Taylor & Francis Ltd
Taylor & Francis Group
한국통합생물학회
Subjects
C2C12
Differentiation
miR-127-3p
miRNA
Muscles
Musculoskeletal system
Myoblasts
Myogenesis
Regulatory mechanisms (biology)
Ribonucleic acid
RNA
Skeletal muscle
Vamp2
생물학
C2C12
miR-127-3p
Vamp2
Myogenesis
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Summary:MicroRNAs (miRNAs) have been reported that can regulate skeletal muscle growth and development. Previously, we demonstrated that miR-127-3p were differently expressed in skeletal muscle and muscle cells. However, the molecular mechanism of miR-127-3p regulation of skeletal myogenesis are not well elucidated. In this study, we transfected miR-127-3p into C2C12 cells, and found miR-127-3p induces myogenesis by targeting Vamp2. Moreover, the regulatory mechanism of Vamp2 in myoblasts proliferation and differentiation was further confirmed. In conclusion, our data providedevidences that miR-127-3p reciprocally regulated myoblasts proliferation and differentiation through directly targeting Vamp2.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1976-8354
2151-2485
DOI:10.1080/19768354.2018.1512520