Regulatory Roles of Flavonoids in Caspase-11 Non-Canonical Inflammasome-Mediated Inflammatory Responses and Diseases

• Published in: International journal of molecular sciences Vol. 24; no. 12; p. 10402
• Main Author: Yi, Young-Su
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2023; MDPI
• Subjects: anti-inflammatory; Bioactive compounds; Cancer; Caspase-11; Caspase-4; Citrus; Citrus fruits; Cocoa; Cytokines; flavonoid; Flavonoids; Fruits; Functional foods & nutraceuticals; Inflammasomes; Inflammation; inflammatory disease; Inflammatory diseases; Isoflavones; Medical research; Medicine, Experimental; Metabolic disorders; Metabolites; non-canonical inflammasome; nutraceutical; Pharmacology; Plants (botany); Pyroptosis; Review; Roles; Vegetables; anti-inflammatory; inflammatory disease; flavonoid; non-canonical inflammasome; nutraceutical
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms241210402

Inflammasomes are multiprotein complexes that activate inflammatory responses by inducing pyroptosis and secretion of pro-inflammatory cytokines. Along with many previous studies on inflammatory responses and diseases induced by canonical inflammasomes, an increasing number of studies have demonstrated that non-canonical inflammasomes, such as mouse caspase-11 and human caspase-4 inflammasomes, are emerging key players in inflammatory responses and various diseases. Flavonoids are natural bioactive compounds found in plants, fruits, vegetables, and teas and have pharmacological properties in a wide range of human diseases. Many studies have successfully demonstrated that flavonoids play an anti-inflammatory role and ameliorate many inflammatory diseases by inhibiting canonical inflammasomes. Others have demonstrated the anti-inflammatory roles of flavonoids in inflammatory responses and various diseases, with a new mechanism by which flavonoids inhibit non-canonical inflammasomes. This review discusses recent studies that have investigated the anti-inflammatory roles and pharmacological properties of flavonoids in inflammatory responses and diseases induced by non-canonical inflammasomes and further provides insight into developing flavonoid-based therapeutics as potential nutraceuticals against human inflammatory diseases.