Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior

• Published in: Cell & bioscience Vol. 14; no. 1; p. 47
• Main Authors: Wei, Huimin, Jiang, Huimin, Zhou, Yifan, Liu, Lu, Ma, Wei, Ni, Shanshan, Zhou, Chen, Ji, Xunming
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.04.2024; BioMed Central; BMC
• Subjects: Acoustics; Animals; Auditory pathways; Auditory plasticity; Blood; Brain; Brain metabolic activity; Central nervous system; Cerebral blood flow; Cerebral circulation; Cerebral venous congestion; CNS homeostatic plasticity; GABA; Hearing loss; Homeostasis; Homeostatic plasticity; Neural plasticity; Neuroimaging; Neurons; Neurophysiology; Proteins; Synaptic strength; Synaptic transmission; Tinnitus; Veins & arteries; γ-Aminobutyric acid; United States > US; Cerebral venous congestion; Tinnitus; Brain metabolic activity; CNS homeostatic plasticity; Cerebral circulation
• ISSN: 2045-3701; 2045-3701
• DOI: 10.1186/s13578-024-01221-9

Brain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral venous system (CVS) contains approximately 70% of the total cerebral blood volume; similar to the cerebral arterial system, the CVS plays a prominent role in the maintenance of central nervous system (CNS) homeostasis. Impaired venous autoregulation, which can appear in forms such as cerebral venous congestion, may lead to metabolic abnormalities in the brain, causing severe cerebral functional defects and even chronic tinnitus. However, the role of cerebral venous congestion in the progression of tinnitus is underrecognized, and its pathophysiology is still incompletely understood. This study elucidated the specific pathogenetic role of cerebral venous congestion in the onset and persistence of tinnitus and the possible neurophysiological mechanisms. We found that a rat model of cerebral venous congestion exhibited tinnitus-like behavioral manifestations at 14 days postoperatively; from that point onward, they showed signs of persistent tinnitus without significant hearing impairment. Subsequent neuroimaging and neurochemical findings showed CNS homeostatic plasticity disturbance in rats with cerebral venous congestion, reflected in increased neural metabolic activity, ultrastructural synaptic changes, upregulated synaptic efficacy, reduced inhibitory synaptic transmission (due to GABA deficiency), and elevated expression of neuroplasticity-related proteins in central auditory and extra-auditory pathways. Collectively, our data suggest that alternations in CNS homeostatic plasticity may play a vital role in tinnitus pathology caused by cerebral venous congestion. These findings provide a new perspective on tinnitus related to cerebral venous congestion and may facilitate the development of precise interventions to interrupt its pathogenesis.