Decoy Receptors Regulation by Resveratrol in Lipopolysaccharide-Activated Microglia

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 5; p. 681
• Main Authors: Calvello, Rosa, Porro, Chiara, Lofrumento, Dario Domenico, Ruggiero, Melania, Panaro, Maria Antonietta, Cianciulli, Antonia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.02.2023; MDPI
• Subjects: Alzheimer's disease; Analysis; Anti-Inflammatory Agents - metabolism; Bioavailability; Care and treatment; Cell culture; Chemokine receptors; Chemokines; Chronic diseases; Cytokines; Cytokines - metabolism; decoy receptors; Diabetes mellitus; Diagnosis; Dosage and administration; Glycerol; Heart diseases; Inflammation; Interleukin 1 receptors; lipopolysaccharide; Lipopolysaccharides; Lipopolysaccharides - metabolism; Microglia; Microglia - metabolism; Movement disorders; Neurodegenerative diseases; Parkinson's disease; Polymerase chain reaction; Proteins; Resveratrol; Resveratrol - metabolism; Risk factors; Signal transduction; Italy; United States > US; decoy receptors; cytokines; lipopolysaccharide; microglia; resveratrol
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells12050681

Resveratrol is a polyphenol that acts as antioxidants do, protecting the body against diseases, such as diabetes, cancer, heart disease, and neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's diseases (PD). In the present study, we report that the treatment of activated microglia with resveratrol after prolonged exposure to lipopolysaccharide is not only able to modulate pro-inflammatory responses, but it also up-regulates the expression of decoy receptors, IL-1R2 and ACKR2 (atypical chemokine receptors), also known as negative regulatory receptors, which are able to reduce the functional responses promoting the resolution of inflammation. This result might constitute a hitherto unknown anti-inflammatory mechanism exerted by resveratrol on activated microglia.