Novel Structural Elements within the Nonproteolytic Clostridium botulinum Type F Toxin Gene Cluster

We sequenced for the first time the complete neurotoxin gene cluster of a nonproteolytic Clostridium botulinum type F. The neurotoxin gene cluster contained a novel gene arrangement that, compared to other C. botulinum neurotoxin gene clusters, lacked the regulatory botR gene and contained an interg...

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Bibliographic Details
Published inApplied and Environmental Microbiology Vol. 77; no. 5; pp. 1904 - 1906
Main Authors Dover, N, Barash, J.R, Hill, K.K, Detter, J.C, Arnon, S.S
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.03.2011
American Society for Microbiology (ASM)
Subjects
Bacteria
Biological and medical sciences
Clostridium botulinum
Clostridium botulinum - genetics
Clostridium botulinum type F - genetics
DNA Transposable Elements
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
Fundamental and applied biological sciences. Psychology
Genes
Genes, Bacterial
Genetics and Molecular Biology
Microbiology
Molecular Sequence Data
Multigene Family
Neurotoxicity
Open Reading Frames
Sequence Analysis, DNA
Toxins
Transcription Factors - genetics
Peptidases
Gene cluster
Bontoxilysin
Clostridium botulinum
Enzyme
Clostridiaceae
Clostridiales
Bacteria
Hydrolases
Metalloendopeptidases
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Summary:We sequenced for the first time the complete neurotoxin gene cluster of a nonproteolytic Clostridium botulinum type F. The neurotoxin gene cluster contained a novel gene arrangement that, compared to other C. botulinum neurotoxin gene clusters, lacked the regulatory botR gene and contained an intergenic is element between its orfX2 and orfX3 genes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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USDOE Office of Science (SC), Biological and Environmental Research (BER)
ISSN:0099-2240
1098-5336
DOI:10.1128/AEM.02422-10