Organokines in COVID-19: A Systematic Review

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 10; p. 1349
• Main Authors: Barbalho, Sandra Maria, Minniti, Giulia, Miola, Vitor Fernando Bordin, Haber, Jesselina Francisco Dos Santos, Bueno, Patrícia Cincotto Dos Santos, de Argollo Haber, Luiza Santos, Girio, Raul S J, Detregiachi, Cláudia Rucco Penteado, Dall'Antonia, Camila Tiveron, Rodrigues, Victória Dogani, Nicolau, Claudia C T, Catharin, Virginia Maria Cavallari Strozze, Araújo, Adriano Cressoni, Laurindo, Lucas Fornari
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.05.2023; MDPI
• Subjects: adipokines; Antigens; Cohort analysis; Coronaviruses; COVID-19; Cross-sectional studies; Cytokine storm; Dendritic cells; Disease transmission; Genomes; Humans; Identification and classification; Immune response; Immunology; Infections; Inflammation; Lymphocytes; Middle East respiratory syndrome; Multiple organ dysfunction syndrome; myokines; Observational studies; organokines; osteokines; Pandemics; Pathophysiology; Peptides; Physiological aspects; Proteins; Respiratory diseases; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Systematic Review; T cell receptors; Viral infections; Viremia; Viruses; Brazil; COVID-19; SARS-CoV-2; hepatokines; viral infection; organokines; osteokines; immune system; cardiokines; adipokines; myokines; pandemic
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells12101349

Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, and Cochrane databases were searched, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and 37 studies were selected, comprising more than 2700 individuals infected with the virus. Among COVID-19 patients, organokines have been associated with endothelial dysfunction and multiple organ failure due to augmented cytokines and increased SARS-CoV-2 viremia. Changes in the pattern of organokines secretion can directly or indirectly contribute to aggravating the infection, promoting immune response alterations, and predicting the disease progression. These molecules have the potential to be used as adjuvant biomarkers to predict the severity of the illness and severe outcomes.