Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 10; no. 4; pp. 293 - 297
• Main Authors: Pavithra, B.H., Animal and Fishery Sciences University, Bidar, India, Prakash, N., Animal and Fishery Sciences University, Bidar, India, Jayakumar, K., Veterinary College, Hebbal Campus, Bangalore, India
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 01.12.2009; The Korean Society of Veterinary Science
• Subjects: ADMINISTRACION ORAL; ADMINISTRATION ORALE; Animals; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Area Under Curve; CONEJO (ORYCTOLAGUS); CURCUMA LONGA; Curcumin - pharmacology; Female; Half-Life; Herb-Drug Interactions; LAPIN (ORYCTOLAGUS); Male; MEDICINAL PROPERTIES; norfloxacin; Norfloxacin - blood; Norfloxacin - pharmacokinetics; ORAL ADMINISTRATION; Original; PROPIEDADES MEDICINALES; PROPRIETE PHARMACOLOGIQUE; RABBITS; 수의학; pharmacokinetics; oral administration; curcuma longa; norfloxacin; rabbits
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2009.10.4.293

Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided into two groups of eight each consisting of either sex. Animals in group-Ⅰ were administered norfloxacin (100 mg/kg body weight p.o), while animals in group-Ⅱ received similar dose of norfloxacin after pre-treatment with curcumin (60 mg/kg body weight per day, 3 days, p.o). Blood samples were drawn from the marginal ear vein into heparin-coated vials at 0 (zero time), 5, 10, 15, 30 min and 1, 2, 4, 6, 12 and 24 h post-treatment. Plasma norfloxacin concentrations were determined by high performance liquid chromatography. The plasma concentration-time profile of norfloxacin was adequately described by a one-compartment open model. The pharmacokinetic data revealed that curcumin-treated animals had significantly (p less-than or equal to 0.05) higher area under the plasma concentration-time curve and area under the first moment of plasma drug concentration-time curve. Prior treatment of curcumin significantly (p less-than or equal to 0.05) increased elimination half-life and volume of distribution of norfloxacin. Further treatment with curcumin reduced loading and maintenance doses by 26% and 24% respectively.