Proteomic Modulation in TGF-β-Treated Cholangiocytes Induced by Curcumin Nanoparticles

• Published in: International journal of molecular sciences Vol. 24; no. 13; p. 10481
• Main Authors: Ceccherini, Elisa, Signore, Giovanni, Tedeschi, Lorena, Vozzi, Federico, Di Giorgi, Nicoletta, Michelucci, Elena, Cecchettini, Antonella, Rocchiccioli, Silvia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.06.2023; MDPI
• Subjects: Analysis; Anti-Inflammatory Agents; Apoptosis; Bioavailability; Carcinogens; Cell cycle; Cell death; cholangiocytes; Comparative analysis; Curcumin; Curcumin - pharmacology; Cytokines; Data analysis; Deregulation; Fibrosis; Growth factors; Health aspects; Humans; Inflammation; Investigations; LC-MS/MS; Liver; Liver - metabolism; Mass spectra; Mediation; Membrane permeability; Metabolism; Nanoparticles; Permeability; Pharmaceutical industry; Phytochemicals; Proteins; Proteomes; Proteomics; TGF-β; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Transforming growth factors; United States; Massachusetts; Germany; LC-MS/MS; TGF-β; nanoparticles; cholangiocytes; proteomics; curcumin

Curcumin is a natural polyphenol that exhibits a variety of beneficial effects on health, including anti-inflammatory, antioxidant, and hepato-protective properties. Due to its poor water solubility and membrane permeability, in the present study, we prepared and characterized a water-stable, freely...