Histochemical Study of the Alcianophilia of Paget Cells in Extramammary Paget's Disease

By applying the concept of critical salt concentration to the differentiation of polyanions, the alcianophilia of the cytoplasm of Paget cells was compar-ed with that of melanoma cell cytoplasm. Methylation, saponification, and hyaluronidase, sialidase, ribonuclease and desoxyribonuclease digestions...

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Published inThe Tohoku Journal of Experimental Medicine Vol. 97; no. 4; pp. 289 - 295
Main Authors Sasai, Yoichiro, Tanahashi, Yoshio
Format Journal Article
LanguageEnglish
Published Japan Tohoku University Medical Press 01.01.1969
Subjects
Biopsy
Cytoplasm
Deoxyribonucleases
Histocytochemistry
Humans
Hyaluronoglucosaminidase
Ions
Melanoma - pathology
Methylation
Neuraminidase
Nucleic Acids
Paget Disease, Extramammary - pathology
Ribonucleases
Skin - pathology
Skin Neoplasms - pathology
Staining and Labeling
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Summary:By applying the concept of critical salt concentration to the differentiation of polyanions, the alcianophilia of the cytoplasm of Paget cells was compar-ed with that of melanoma cell cytoplasm. Methylation, saponification, and hyaluronidase, sialidase, ribonuclease and desoxyribonuclease digestions were employed in a further attempt to identify histochemically various polyanions. The results suggest that the alcianophilia of the cytoplasm of Paget cells is mainly due to carboxyl group-containing polyanions, while that of melanoma cell cyto-plasm is related to nucleic acid.
Bibliography:ObjectType-Article-1
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ISSN:0040-8727
1349-3329
DOI:10.1620/tjem.97.289