CD4 T-cell immunotherapy for chronic viral infections and cancer

• Published in: Immunotherapy Vol. 5; no. 9; pp. 975 - 987
• Main Authors: Kamphorst, Alice O, Ahmed, Rafi
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.09.2013
• Subjects: adoptive cell transfer; Adoptive immunotherapy; Adoptive Transfer - methods; Animals; B-Lymphocytes - immunology; B-Lymphocytes - pathology; cancer; Care and treatment; CD4 lymphocytes; CD4 T cells; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - transplantation; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; Cellular therapy; Chronic Disease; chronic infection; exhaustion; Humans; Immune response; Immune system; Immunity, Innate; Immunology; immunotherapy; Infections; Neoplasms - immunology; Neoplasms - pathology; Neoplasms - therapy; Observations; PD-1; Properties; T cell receptors; Testing; Viral infections; Virus diseases; Virus Diseases - immunology; Virus Diseases - pathology; Virus Diseases - therapy; United Kingdom

During chronic infections and cancer, T cells progressively lose function and become exhausted. However, effective T-cell responses are necessary to ultimately control viral infections and tumors. Hence, strategies that either restore endogenous immune responses or provide functional T cells by adop...