Application of Nanocellulose-Based Aerogels in Bone Tissue Engineering: Current Trends and Outlooks

The complex or compromised bone defects caused by osteomyelitis, malignant tumors, metastatic tumors, skeletal abnormalities, and systemic diseases are difficult to be self-repaired, leading to a non-union fracture. With the increasing demands of bone transplantation, more and more attention has bee...

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Published inPolymers Vol. 15; no. 10; p. 2323
Main Authors Zhang, Yaoguang, Jiang, Shengjun, Xu, Dongdong, Li, Zubing, Guo, Jie, Li, Zhi, Cheng, Gu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.05.2023
MDPI
Subjects
Abnormalities
aerogel
Aerogels
Biomedical materials
Biopolymers
bone defect
bone tissue engineering
Bones
Caustic soda
Cellulose
Chemical reactions
Composite fabrication
Flexibility
Forecasts and trends
Glucose
Homogenization
Lignin
Mechanical properties
nanocellulose
Review
Skin & tissue grafts
Substitute bone
Tissue engineering
Transplantation
Transplantation of organs, tissues, etc
Tumors
China
nanocellulose
bone defect
bone tissue engineering
aerogel
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Summary:The complex or compromised bone defects caused by osteomyelitis, malignant tumors, metastatic tumors, skeletal abnormalities, and systemic diseases are difficult to be self-repaired, leading to a non-union fracture. With the increasing demands of bone transplantation, more and more attention has been paid to artificial bone substitutes. As biopolymer-based aerogel materials, nanocellulose aerogels have been widely utilized in bone tissue engineering. More importantly, nanocellulose aerogels not only mimic the structure of the extracellular matrix but could also deliver drugs and bioactive molecules to promote tissue healing and growth. Here, we reviewed the most recent literature about nanocellulose-based aerogels, summarized the preparation, modification, composite fabrication, and applications of nanocellulose-based aerogels in bone tissue engineering, as well as giving special focus to the current limitations and future opportunities of nanocellulose aerogels for bone tissue engineering.
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These authors contributed equally to this work.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym15102323