Novel Utilization of Therapeutic Coatings Based on Infiltrated Encapsulated Rose Bengal Microspheres in Porous Titanium for Implant Applications

Despite the increasing progress achieved in the last 20 years in both the fabrication of porous dental implants and the development of new biopolymers for targeting drug therapy, there are important issues such as bone resorption, poor osseointegration, and bacterial infections that remain as critic...

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Published inPharmaceutics Vol. 14; no. 6; p. 1244
Main Authors Accioni, Francesca, Rassu, Giovanna, Begines, Belén, Rodríguez-Albelo, Luisa Marleny, Torres, Yadir, Alcudia, Ana, Gavini, Elisabetta
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 12.06.2022
MDPI
Subjects
Antibiotics
Antimicrobial agents
Bacteria
biomaterials
Biomechanics
Care and treatment
Coatings
Dental implants
drug delivery
Drug resistance
FDA approval
Gram-positive bacteria
Health aspects
Implant dentures
implants
Infections
Materials
Microspheres
Polyvinyl alcohol
porous titanium
rose bengal
Titanium
Topography
Italy
United States > US
Germany
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Summary:Despite the increasing progress achieved in the last 20 years in both the fabrication of porous dental implants and the development of new biopolymers for targeting drug therapy, there are important issues such as bone resorption, poor osseointegration, and bacterial infections that remain as critical challenges to avoid clinical failure problems. In this work, we present a novel microtechnology based on polycaprolactone microspheres that can adhere to porous titanium implant models obtained by the spacer holder technique to allow a custom biomechanical and biofunctional balance. For this purpose, a double emulsion solvent evaporation technique was successfully employed for the fabrication of the microparticles properly loaded with the antibacterial therapeutic agent, rose bengal. The resulting microspheres were infiltrated into porous titanium substrate and sintered at 60 °C for 1 h, obtaining a convenient prophylactic network. In fact, the sintered polymeric microparticles were demonstrated to be key to controlling the drug dissolution rate and favoring the early healing process as consequence of a better wettability of the porous titanium substrate to promote calcium phosphate nucleation. Thus, this joint technology proposes a suitable prophylactic tool to prevent both early-stage infection and late-stage osseointegration problems.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14061244