Chemistry, Biosynthesis and Pharmacology of Streptonigrin: An Old Molecule with Future Prospects for New Drug Design, Development and Therapy

• Published in: Drug design, development and therapy Vol. 17; pp. 1065 - 1078
• Main Authors: Nabihah Nasir, Naurah, Sekar, Mahendran, Ravi, Subban, Wong, Ling Shing, Sisinthy, Sreenivas Patro, Gan, Siew Hua, Subramaniyan, Vetriselvan, Chidambaram, Kumarappan, Mat Rani, Nur Najihah Izzati, Begum, M Yasmin, Ramar, Mohankumar, Safi, Sher Zaman, Selvaraj, Siddharthan, Chinna Maruthu, Senthil Kumar, Fuloria, Shivkanya, Fuloria, Neeraj Kumar, Lum, Pei Teng, Djearamane, Sinouvassane
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2023; Dove; Dove Medical Press
• Subjects: antibacterial; Antibiotics; anticancer; Antineoplastic Agents - pharmacology; Biosynthesis; chemistry; Drug Design; Drug discovery; Pharmacology; Physiological aspects; Review; Streptonigrin; Malaysia; chemistry; antibacterial; anticancer; biosynthesis; pharmacology; streptonigrin

Streptonigrin is an aminoquinone alkaloid isolated from and is gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It was previously used as an anticancer drug but has been discontinued because of its toxic effects. However, according to the most recent stud...