Polarized Th2 cells attenuate high-fat-diet induced obesity through the suppression of lipogenesis

• Published in: BMC immunology Vol. 25; no. 1; p. 4
• Main Authors: Dong, Lijun, Gao, Jingtao, Yu, Lu, Liu, Shibo, Zhao, Yuxin, Zhang, Wen, Liang, Yinming, Wang, Hui
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.01.2024; BioMed Central; BMC
• Subjects: Adipocyte; Adipocytes; Adipose tissue; Adipose tissues; Adoptive Transfer; Animals; Antibodies; B cells; Beta cells; Body fat; Care and treatment; Cell therapy; Cholesterol; Cytokines; Dextrose; Diagnosis; Diet; Diet, High-Fat - adverse effects; Exercise; Fatty liver; Glucose; Glucose tolerance; Helper cells; High fat diet; Inflammation; Insulin resistance; Leukocytes (neutrophilic); Lipogenesis; Lymphocytes T; Macrophages; Male; Metabolism; Mice; Neutrophils; Obesity; Obesity - therapy; Oxidative phosphorylation; Penicillin; Phosphorylation; Prevention; Risk factors; Steatosis; T cells; Th2; Th2 Cells; Type 2 diabetes; China; United States > US; Adipocyte; Obesity; Lipogenesis; High fat diet; Th2
• ISSN: 1471-2172; 1471-2172
• DOI: 10.1186/s12865-024-00598-z

Immune cells, such as macrophages, B cells, neutrophils and T cell subsets, have been implicated in the context of obesity. However, the specific role of Th2 cells in adipose tissue function has remained elusive. Eight-week-old male CD3ε mice were randomly divided into two groups (≥ 5 mice per group): one received intravenous injection of Th2 cells isolated from LAT mice, while the other receiving PBS as a control. Both of groups were subjected to a high-fat diet (HFD). The adoptive transfer of polarized Th2 cells led to a significant reduction in obesity following a HFD. This reduction was accompanied by improvements in hepatic steatosis, glucose intolerance, and insulin resistance. Mechanistically, Th2 cell treatment promoted oxidative phosphorylation of adipocytes, thereby contributing to a reduction of lipid droplet accumulation. These findings suggest that Th2 cell therapy represents a novel approach for treating diet-induced obesity and other diseases involving lipid droplet accumulation disorders.