Examination of the percentage of immature platelet fraction in term and preterm infants at birth

Background: Reticulated platelets (RPs) are newly synthesized platelets. Recently, an automatic method was established to detect RPs as a percentage of the immature platelet fraction (IPF%). Although, neonates often develop thrombocytopenia at some time during their hospitalization, the details of I...

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Published inJournal of clinical neonatology Vol. 2; no. 4; pp. 173 - 178
Main Authors Yuko, Sakurai, Takeda, Tomohiro, Hirota, Atsushi, Hisaeda, Yoshiya, Amakata, Syusuke, Nakao, Atsushi, Kawakami, Tadashi
Format Journal Article
LanguageEnglish
Published India Medknow Publications Pvt Ltd 01.10.2013
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
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Summary:Background: Reticulated platelets (RPs) are newly synthesized platelets. Recently, an automatic method was established to detect RPs as a percentage of the immature platelet fraction (IPF%). Although, neonates often develop thrombocytopenia at some time during their hospitalization, the details of IPF% in neonates remain unclear. We, therefore, studied the relations between IPF% and other factors to gain a more detailed understanding of IPF% in neonates. Methods: The following clinical data were obtained from the medical records of 105 neonates who met our inclusion criteria: Gestational age, birth weight, IPF% and platelet count of neonatal peripheral blood at birth, and perinatal data. The subjects were divided into three groups: Group A, birth weight standard deviation score (SDS) ≥ −2 standard deviation (SD) and ≤ +2 SD; Group S, < −2 SD; and Group L, > +2 SD. Results: IPF% correlated negatively with platelet count at birth in the whole study population. IPF% was 2.8 ± 1.3% in term neonates, and IPF correlated negatively with gestational age and birth weight. Platelet count correlated positively with birth weight SDS in the whole study population and in Group S. IPF% correlated negatively with birth weight SDS in the whole study population and in Group S. In neonates with a platelet count below 25 Χ 10 4 /μl, IPF% correlated negatively with platelet count. Among other neonates, however, IPF% remained almost constant. Conclusion: Monitoring of IPF% is useful for estimating the function of thrombocytopoiesis in neonates and preterm infants.
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ISSN:2249-4847
1658-6093
DOI:10.4103/2249-4847.123095