Cytotoxic Properties of Polyurethane Foams for Biomedical Applications as a Function of Isocyanate Index

Polyurethane foams are widely used in biomedical applications due to their desirable mechanical properties and biocompatibility. However, the cytotoxicity of its raw materials can limit their use in certain applications. In this study, a group of open-cell polyurethane foams were investigated for th...

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Published inPolymers Vol. 15; no. 12; p. 2754
Main Authors Grzęda, Dominik, Węgrzyk, Grzegorz, Nowak, Adriana, Idaszek, Joanna, Szczepkowski, Leonard, Ryszkowska, Joanna
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.06.2023
MDPI
Subjects
Accuracy
Biocompatibility
biomedical
Biomedical engineering
Biomedical materials
Carbon dioxide
composite matrix
Cytotoxicity
foams
Isocyanates
Life sciences
Mechanical properties
Medical research
Medicine
Mineral industry
Mining industry
Molecular weight
Nanoparticles
open-cell
Pharmaceutical industry
Plastic foam
polyurethane
Polyurethane foam
Polyurethanes
Pressure ulcers
Raw materials
Scientific equipment and supplies industry
Spectrum analysis
Surfactants
Technology application
Toxicity
Transplants & implants
Poland
Canada
United States
Germany
United States > US
polyurethane
biomedical
cytotoxicity
composite matrix
open-cell
foams
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Summary:Polyurethane foams are widely used in biomedical applications due to their desirable mechanical properties and biocompatibility. However, the cytotoxicity of its raw materials can limit their use in certain applications. In this study, a group of open-cell polyurethane foams were investigated for their cytotoxic properties as a function of the isocyanate index, a critical parameter in the synthesis of polyurethanes. The foams were synthesized using a variety of isocyanate indices and characterized for their chemical structure and cytotoxicity. This study indicates that the isocyanate index highly influences the chemical structure of polyurethane foams, also causing changes in cytotoxicity. These findings have important implications for designing and using polyurethane foams as composite matrices in biomedical applications, as careful consideration of the isocyanate index is necessary to ensure biocompatibility.
Bibliography:ObjectType-Article-1
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym15122754