Effects of HTLV-1 on leukocyte trafficking and migration in ACs compared to healthy individuals

• Published in: BMC research notes Vol. 17; no. 1; pp. 222 - 6
• Main Authors: Letafati, Arash, Bahavar, Atefeh, Norouzi, Mehdi, Rasouli, Aziz, Hedayatyaghoubi, Mojtaba, Molaverdi, Ghazale, Mozhgani, Sayed-Hamidreza, Siami, Zeinab
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.08.2024; BioMed Central; BMC
• Subjects: ACs; Adult; Adult T-cell leukemia-lymphoma; Analysis; Asymptomatic; ATLL; Basic-Leucine Zipper Transcription Factors; Case-Control Studies; Cell adhesion & migration; Cell migration; Cell Movement; Central nervous system diseases; CXCR4 protein; Development and progression; Female; Gene expression; Gene Products, tax - genetics; Genes; Genetic aspects; HAM/TSP; Health aspects; Hereditary spastic paraplegia; HTLV-1; HTLV-I Infections - genetics; HTLV-I Infections - immunology; HTLV-I Infections - virology; Human T-lymphotropic virus 1 - genetics; Human T-lymphotropic virus 1 - physiology; Humans; Infections; Inflammation; Kinases; Leukocyte migration; Leukocytes; Leukocytes - immunology; Leukocytes - metabolism; Lymphocyte Function-Associated Antigen-1 - genetics; Lymphocyte Function-Associated Antigen-1 - metabolism; Lymphocytes; Lymphocytes T; Lymphoma; Male; Males; Metastasis; Middle Aged; Motility; MRNA expression; Myosin-light-chain kinase; Nervous system; Proteins; Proto-Oncogene Proteins c-vav - genetics; Proto-Oncogene Proteins c-vav - metabolism; Rac1 protein; Receptors, CXCR4 - genetics; Receptors, CXCR4 - metabolism; Research Note; Retroviridae Proteins; rho-Associated Kinases - genetics; rho-Associated Kinases - metabolism; Risk factors; RNA viruses; RNA, Messenger - genetics; RNA, Messenger - metabolism; Spinal cord; Tropical spastic paraparesis; Iran; Germany; ACs; HAM/TSP; MRNA expression; HTLV-1; ATLL; Cell migration

Human T-lymphotropic virus type 1 (HTLV-1) is a RNA virus belonging to Retroviridae family and is associated with the development of various diseases, including adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Aside from HAM/TSP, HTLV-1 h...