Effects of HTLV-1 on leukocyte trafficking and migration in ACs compared to healthy individuals

• Published in: BMC research notes Vol. 17; no. 1; pp. 222 - 6
• Main Authors: Letafati, Arash, Bahavar, Atefeh, Norouzi, Mehdi, Rasouli, Aziz, Hedayatyaghoubi, Mojtaba, Molaverdi, Ghazale, Mozhgani, Sayed-Hamidreza, Siami, Zeinab
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.08.2024; BioMed Central; BMC
• Subjects: ACs; Adult; Adult T-cell leukemia-lymphoma; Analysis; Asymptomatic; ATLL; Basic-Leucine Zipper Transcription Factors; Case-Control Studies; Cell adhesion & migration; Cell migration; Cell Movement; Central nervous system diseases; CXCR4 protein; Development and progression; Female; Gene expression; Gene Products, tax - genetics; Genes; Genetic aspects; HAM/TSP; Health aspects; Hereditary spastic paraplegia; HTLV-1; HTLV-I Infections - genetics; HTLV-I Infections - immunology; HTLV-I Infections - virology; Human T-lymphotropic virus 1 - genetics; Human T-lymphotropic virus 1 - physiology; Humans; Infections; Inflammation; Kinases; Leukocyte migration; Leukocytes; Leukocytes - immunology; Leukocytes - metabolism; Lymphocyte Function-Associated Antigen-1 - genetics; Lymphocyte Function-Associated Antigen-1 - metabolism; Lymphocytes; Lymphocytes T; Lymphoma; Male; Males; Metastasis; Middle Aged; Motility; MRNA expression; Myosin-light-chain kinase; Nervous system; Proteins; Proto-Oncogene Proteins c-vav - genetics; Proto-Oncogene Proteins c-vav - metabolism; Rac1 protein; Receptors, CXCR4 - genetics; Receptors, CXCR4 - metabolism; Research Note; Retroviridae Proteins; rho-Associated Kinases - genetics; rho-Associated Kinases - metabolism; Risk factors; RNA viruses; RNA, Messenger - genetics; RNA, Messenger - metabolism; Spinal cord; Tropical spastic paraparesis; Iran; Germany; ACs; HAM/TSP; MRNA expression; HTLV-1; ATLL; Cell migration
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-024-06887-5

Human T-lymphotropic virus type 1 (HTLV-1) is a RNA virus belonging to Retroviridae family and is associated with the development of various diseases, including adult T-cell leukemia/lymphoma (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Aside from HAM/TSP, HTLV-1 has been implicated in the development of several disorders that mimic auto-inflammation. T-cell migration is important topic in the context of HTLV-1 associated diseases progression. The primary objective of this case-control study was to assess the relationship between increased mRNA expression in virus migration following HTLV-1 infection. PBMCs from 20 asymptomatic patients and 20 healthy subjects were analyzed using real-time PCR to measure mRNA expression of LFA1, MLCK, RAC1, RAPL, ROCK1, VAV1 and CXCR4. Also, mRNA expression of Tax and HBZ were evaluated. Mean expression of Tax and HBZ in ACs (asymptomatic carriers) was 0.7218 and 0.6517 respectively. The results revealed a noteworthy upregulation of these genes involved in T-cell migration among ACs patients in comparison to healthy individuals. Considering the pivotal role of gene expression alterations associated with the progression into two major diseases (ATLL or HAM/TSP), analyzing the expression of these genes in the ACs group can offer probable potential diagnostic markers and aid in monitoring the condition of ACs.