Remote Ischemic Conditioning Reduces Myocardial Infarct Size in STEMI Patients Treated by Thrombolysis

• Published in: Journal of the American College of Cardiology Vol. 65; no. 25; pp. 2764 - 2765
• Main Authors: Yellon, Derek M., DSc, PhD, Ackbarkhan, Akbar K., MD, Balgobin, Vinod, MD, Bulluck, Heerajnarain, MBBS, Deelchand, Anil, DPH, Dhuny, Mohammad R., MD, Domah, Nizam, MD, Gaoneadry, Dhunujnaye, DMS, Jagessur, Rabindranath K., MD, PhD, Joonas, Noorjehan, PhD, Kowlessur, Sudhir, MA, Lutchoo, Jairajsing, PhD, Nicholas, Jennifer M., PhD, Pauvaday, Keyvoobalan, MBChB, Shamloll, Oomesh, MBBS, Walker, John M., BSc, MBChB, MD, Hausenloy, Derek J., MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.06.2015; Elsevier Limited
• Subjects: Biomedical research; Cardiology; Cardiovascular; Confidence intervals; Female; Heart attacks; Humans; Internal Medicine; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Myocardial Infarction - pathology; Myocardial Infarction - therapy; Quality of life; Thrombolytic Therapy; Mauritius
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2015.02.082

In this regard, the heart can be protected against MI by simply applying cycles of brief ischemia and/or reperfusion to the arm or leg, which is termed remote ischemic conditioning (RIC) (2). [...]we hypothesized that RIC initiated on arrival at the hospital and before thrombolysis could reduce enzymatic MI size in STEMI patients (ERIC-LYSIS [Effect of Remote Ischemic Conditioning in Heart Attack Patients] Study; NCT02197117). [...]we have shown that RIC reduced MI size in STEMI patients treated with thrombolysis, making this noninvasive, easily applied, low-cost therapy an attractive option in developing nations where health care resources are limited and current therapy is not optimal.