The development of the occurrence and metastasis of breast cancer by single-cell sequencing

• Published in: Cancer cell international Vol. 24; no. 1; pp. 349 - 8
• Main Authors: Chen, Man, Feng, Mengya, Lei, Hai, Dan Mo, Ren, Shengnan, Yang, Dechun
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26.10.2024; BMC
• Subjects: Breast cancer; Cell survival; DNA methylation; Genomics; Metabolites; Metastases; Mutation; Review; Single-cell sequencing; Tumor metastasis; Tumor occurrence; Single-cell sequencing; Breast cancer; Tumor occurrence; Tumor metastasis
• ISSN: 1475-2867; 1475-2867
• DOI: 10.1186/s12935-024-03531-x

Breast cancer is currently the most frequent malignant tumor and the leading cause of cancer death among women globally. Although the five-year survival rate for early breast cancer has risen to more than 90%, medication resistance persists in advanced breast cancer and some intractable breast cancer, resulting in a poor prognosis, a high recurrence rate, and a low survival rate. Single-cell sequencing (SCS) is the study of a single cell's gene structure and expression level differences in order to discover unusual molecular subgroups, disease development, and a variety of mechanisms. This review briefly discusses single-cell sequencing and its application, and lists the research on single-cell sequencing in the development and metastasis of breast cancer, in order to bring fresh ideas for the comprehensive treatment of breast cancer.