A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China

• Published in: International journal of hematology Vol. 88; no. 2; pp. 165 - 173
• Main Authors: Gross, Sherilyn A., Zhu, Xiongzeng, Bao, Liming, Ryder, John, Le, Anh, Chen, Yan, Wang, Xiao Qin, Irons, Richard D.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.09.2008; Springer; Springer Nature B.V
• Subjects: Adult; Asian Continental Ancestry Group - statistics & numerical data; Biological and medical sciences; China - epidemiology; DNA, Neoplasm - analysis; Hematologic and hematopoietic diseases; Hematology; Humans; In Situ Hybridization, Fluorescence; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Non-Hodgkin - classification; Lymphoma, Non-Hodgkin - ethnology; Lymphoma, Non-Hodgkin - genetics; Medical sciences; Medicine; Medicine & Public Health; Oncology; Original Article; Prevalence; Prospective Studies; Urban Population - statistics & numerical data; World Health Organization; Asia; China; Non-Hodgkin lymphoma; Prospective study; 2001 WHO diagnostic criteria; Hematology; Malignant hemopathy; Laboratory; Non Hodgkin lymphoma; Case study; Prospective; Lymphoproliferative syndrome; Diagnosis; Cancer; WHO
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-008-0132-1

The frequency of subtypes of lymphoid neoplasms was determined in a prospective series of 831 patients presenting at 29 Shanghai hospitals over a 4-year period. Diagnosis and classification was established in a single laboratory according to the 2001 WHO classification system. The frequency of non-Hodgkin lymphoma was 87.6% ( n = 728) and Hodgkin lymphoma was 12.4% ( n = 103). The most prevalent NHL subtypes diagnosed using WHO criteria were diffuse large B cell lymphoma (DLBCL), precursor B lymphoblastic leukemia/lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Although a low incidence has been reported in some Asian populations, CLL/SLL was commonly encountered, indicating that chronic lymphoid neoplasms are not rare in Shanghai. Consistent with previous reports, our findings indicate a decrease in the frequency of follicular lymphoma and an increase in T cell neoplasms compared to the West. Precursor T lymphoblastic leukemia/lymphoma, anaplastic large T cell lymphoma, aggressive NK cell leukemia, angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma were prominent subtypes of T cell NHL.