Do the obsessive-compulsive symptoms have an effect in schizophrenia?

• Published in: Comprehensive psychiatry Vol. 51; no. 4; pp. 357 - 362
• Main Authors: Tiryaki, Ahmet, Özkorumak, Evrim
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2010; Elsevier; Elsevier Limited
• Subjects: Adult; Adult and adolescent clinical studies; Age of Onset; Anxiety disorders. Neuroses; Biological and medical sciences; Comorbidity; Female; Humans; Male; Medical sciences; Neuropsychological Tests; Obsessive-Compulsive Disorder - diagnosis; Obsessive-Compulsive Disorder - epidemiology; Obsessive-Compulsive Disorder - psychology; Obsessive-compulsive disorders; Prevalence; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Quality of life; Quality of Life - psychology; Schizophrenia; Schizophrenia - epidemiology; Schizophrenic Psychology; Severity of Illness Index; Statistics, Nonparametric; Studies; Human; Obsessive compulsive disorder; Anxiety disorder; Schizophrenia; Cognition; Quality of life; Psychosis; Symptomatology; Concomitant disease; Follow up study; Evolution; Severity score; Predictive factor
• ISSN: 0010-440X; 1532-8384
• DOI: 10.1016/j.comppsych.2009.10.007

Abstract Objective Schizophrenia presents with different symptom domains and functionality during its course. Obsessive-compulsive (OC) symptoms in schizophrenia have many themes to be clarified. Our aim was to compare schizophrenia patients with and without OC symptoms in terms of symptom domains, cognitive functions, and quality of life. Method Sixty-two patients who met schizophrenia diagnosis were assessed with Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition consecutively over a period of 12 months in the setting of an outpatient clinic at medical university hospital. Yale-Brown Obsessive-Compulsive Scale, Scale for the Assessment of Negative Symptoms, Scale for the Assessment of Positive Symptoms, and neuropsychologic tests were used. Quality of life was assessed with Quality of Life Scale for Patients with Schizophrenia. Results Obsessive-compulsive symptoms along with schizophrenia were present in a considerable number in our sample (35.5%). Level of psychotic symptoms was more severe and quality of life was lower in schizophrenia patients with OC symptoms. A positive correlation was found between obsessions and delusions. Moreover, there was a positive correlation between compulsions and total Scale for the Assessment of Positive Symptoms score and bizarre behaviors subscore. There was no difference between the 2 groups regarding neurocognitive functions. The level of quality of life of schizophrenic patients with OC symptoms was lower. Besides, no correlation was found between OC symptoms and neurocognition and quality of life. Conclusions The findings of this study indicate that schizophrenia patients with OC symptoms had severe psychotic symptoms with a distinctive clinical picture including good neurocognition but poor functioning.