Antiviral Agents of Plant Origin. II. : Antiviral Activity of Scopadulcic Acid B Derivatives

Scopadulcic acid B derivatives were synthesized and their antiviral activities against herpes simplex virus type 1 (HSV-1) were examined. All the derivatives synthesized showed lower inhibitory activities against HSV-1 than acopadulcic acid B (2). Five compounds, 7, 8, 15, 16, and 18, however, had i...

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Published inChemical & pharmaceutical bulletin Vol. 38; no. 1; pp. 239 - 242
Main Authors HAYASHI, Toshimitsu, HAYASHI, Kyoko, UCHIDA, Kumiko, NIWAYAMA, Seihachiro, MORITA, Naokata
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1990
Maruzen
Subjects
Alicyclic compounds
Alicyclic compounds, terpenoids, prostaglandins, steroids
antiviral activity
Antiviral Agents
Cells, Cultured
Chemistry
cytotoxicity
Diterpenes - pharmacology
diterpenoid
Exact sciences and technology
herpes simplex virus
HSV-1
Organic chemistry
Preparations and properties
scopadulcic acid B
Scoparia dulcis
Simplexvirus - drug effects
Structure-Activity Relationship
Virus
Terpenoid
Structure activity relation
Herpesviridae
Alphaherpesvirinae
Antiviral
Cytotoxicity
Herpesvirus hominis
Tetracyclic compound
Biological activity
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Summary:Scopadulcic acid B derivatives were synthesized and their antiviral activities against herpes simplex virus type 1 (HSV-1) were examined. All the derivatives synthesized showed lower inhibitory activities against HSV-1 than acopadulcic acid B (2). Five compounds, 7, 8, 15, 16, and 18, however, had in vitro therapeutic indexes larger than 7 and were considered to merit further investigation.
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.38.239