Giant cell myocarditis with prolonged cardiac standstill after drug‐induced hypersensitivity syndrome: a case report

Giant cell myocarditis (GCM) is a rare but fatal disease that can lead to cardiac failure. Survival with a cardiac standstill requires mechanical circulatory support or a biventricular assist device (BiVAD) and prolonged survival is extremely rare. Drug‐induced hypersensitivity syndrome (DIHS) is a...

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Bibliographic Details
Published inESC Heart Failure Vol. 11; no. 2; pp. 805 - 810
Main Authors Ono, Ryohei, Kohno, Hiroki, Kaminota, Sae, Aoki, Kaoruko, Kato, Hirotoshi, Iwahana, Togo, Aihara, Takanori, Ota, Masayuki, Matsumiya, Goro, Kobayashi, Yoshio
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.04.2024
John Wiley and Sons Inc
Wiley
Subjects
Biopsy
Biventricular assist device
Cardiac arrest
Cardiac standstill
Case Report
Case reports
Creatinine
Cytomegalovirus
Deoxyribonucleic acid
DNA
Drug dosages
Drug‐induced hypersensitivity syndrome
Dyspnea
Edema
Enzymes
Epstein-Barr virus
Extracorporeal membrane oxygenation
Giant cell myocarditis
Hemoglobin
Herpes viruses
Histopathology
Kinases
Lymphocytes
Myocarditis
Pulmonary arteries
Review
Severe acute respiratory syndrome coronavirus 2
Steroids
Thromboembolism
Veins & arteries
Biventricular assist device
Drug-induced hypersensitivity syndrome
Giant cell myocarditis
Review
Cardiac standstill
Cardiac arrest
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Summary:Giant cell myocarditis (GCM) is a rare but fatal disease that can lead to cardiac failure. Survival with a cardiac standstill requires mechanical circulatory support or a biventricular assist device (BiVAD) and prolonged survival is extremely rare. Drug‐induced hypersensitivity syndrome (DIHS) is a severe cutaneous adverse reaction. Some cases of DIHS are reportedly associated with the onset of GCM. We present a case of a 28‐year‐old woman who developed GCM during steroid tapering after DIHS. She went into continuous cardiac standstill but survived for 74 days under BiVAD support. Our case is noteworthy because the histopathologic specimens obtained on three occasions contributed to the diagnosis of this particular condition over time. We also reviewed previous literature on concomitant cases of GCM and DIHS. We found that two are potentially associated and most cases of GCM occur within 3 months of DIHS during steroid tapering.
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.14678