Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans

The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to you...

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Published inAnnals of neurology Vol. 78; no. 2; pp. 317 - 322
Main Authors Wang, Joshua L., Lim, Andrew S., Chiang, Wei-Yin, Hsieh, Wan-Hsin, Lo, Men-Tzung, Schneider, Julie A., Buchman, Aron S., Bennett, David A., Hu, Kun, Saper, Clifford B.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.08.2015
Wiley Subscription Services, Inc
Subjects
Actigraphy
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Alzheimer Disease - physiopathology
Biological clocks
Case-Control Studies
Cell Count
Circadian rhythm
Circadian Rhythm - physiology
Female
Humans
Male
Middle Aged
Motor Activity - physiology
Neurons - cytology
Neurons - metabolism
Neurons - physiology
Suprachiasmatic Nucleus - cytology
Suprachiasmatic Nucleus - metabolism
Suprachiasmatic Nucleus - physiopathology
Vasoactive Intestinal Peptide - metabolism
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Summary:The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day–night cycle. Older humans, particularly those with Alzheimer disease (AD), often have difficulty maintaining normal circadian rhythms compared to younger adults, but the basis of this change is unknown. We report that the circadian rhythm amplitude of motor activity in both AD subjects and age‐matched controls is correlated with the number of vasoactive intestinal peptide–expressing SCN neurons. AD was additionally associated with delayed circadian phase compared to cognitively healthy subjects, suggesting distinct pathologies and strategies for treating aging‐ and AD‐related circadian disturbances. Ann Neurol 2015;78:317–322
Bibliography:The Illinois Department of Public Health
Dana Foundation Clinical Neuroscience Grant
The US NIH - No. P01AG009975; No. P01HL095491; No. R00HL102241; No. R01NS072337; No. R01AG017917; No. R01AG024480; No. R01NS078009; No. R01AG043379; No. R01AG042210
The Canadian Institutes of Health Research - No. MOP125934; No. MMC132692
The Robert C. Borwell Endowment Fund
ark:/67375/WNG-K3TPKFSG-3
Ministry of Science and Technology of Taiwan support for the Center for Dynamical Biomarkers and Translational Medicine
The CGH-NCU Joint Research Foundation - No. CNJRF-101CGH-NCU-A4; No. VGHUST103-G1-3-3
ArticleID:ANA24432
The Ministry of Science and Technology of Taiwan and National Science Council of Taiwan - No. NSC 102-2911-I-008-001; No. NSC 102-2221-E-008-008; No. NSC 103-2221-E-008-006-MY3
istex:860DDC3C014FE9DEAB6AF57CF1B974A77F7C78B2
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0364-5134
1531-8249
1531-8249
DOI:10.1002/ana.24432