Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice

Externally manipulating memories by presenting conditioned stimuli (CS) during sleep is a new approach to investigating memory processing during sleep. However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated. In this study, mice...

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Bibliographic Details
Published inScientific reports Vol. 7; no. 1; p. 46247
Main Authors Purple, Ross J., Sakurai, Takeshi, Sakaguchi, Masanori
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 12.04.2017
Nature Publishing Group
Subjects
631/378/1385/519
631/378/1595/2636
631/378/1595/2638
Conditioned stimulus
Fear conditioning
Feet
Footshock
Humanities and Social Sciences
Memory
multidisciplinary
NREM sleep
REM sleep
Science
Sleep
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Summary:Externally manipulating memories by presenting conditioned stimuli (CS) during sleep is a new approach to investigating memory processing during sleep. However, whether presenting a CS during REM or NREM sleep enhances or extinguishes fear memory has not been clearly delineated. In this study, mice underwent trace fear conditioning consisting of an auditory CS paired with a foot shock, and the auditory CS was re-presented during subsequent REM or NREM sleep. Mice that received auditory cueing during NREM but not REM sleep showed impaired fear memory upon later presentation of the auditory CS. These findings have implications for the use of cueing during sleep and advance our understanding of the role of REM and NREM sleep in memory consolidation.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep46247