Implementation of the Treat All Policy Among Persons with HIV Infection Enrolled in Care But Not on Antiretroviral Therapy — India, May 2017–June 2018

• Published in: MMWR. Morbidity and mortality weekly report Vol. 67; no. 47; pp. 1305 - 1309
• Main Authors: Mitruka, Kiren, Bamrotiya, Manish, Agarwal, Reshu, Parvez, Anwar, Allam, Ramesh Reddy, Sivalenka, Srilatha, Deoraj, Pramod, Prasad, Rajendra, Devi, Uma, Keskar, Padmaja, Acharya, Shrikala, Kannan, Priya, Ganti, Ramesam, Shah, Malay, Todmal, Shashikant, Kumar, Praveen, Chava, Nalini, Rao, Ajit, Tanwar, Sukarma, Nyendak, Melissa, Ellerbrock, Tedd, Holtz, Timothy H., Gupta, R.S.
• Format: Journal Article Newsletter
• Language: English
• Published: United States Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services 30.11.2018; U.S. Government Printing Office; Centers for Disease Control and Prevention
• Subjects: Care and treatment; Development and progression; Full Report; Health aspects; Highly active antiretroviral therapy; HIV; HIV infections; HIV patients; Morbidity; Mortality; Public health; India
• ISSN: 0149-2195; 1545-861X
• DOI: 10.15585/mmwr.mm6747a2

Since September 2015, the World Health Organization has recommended antiretroviral therapy (ART) for all persons with human immunodeficiency virus (HIV) infection, regardless of clinical stage or CD4 count (1). This Treat All policy was based on evidence that ART initiation early in HIV infection as opposed to waiting for the CD4 count to decline to certain levels (e.g., <500 cells/mm , per previous guidelines), was associated with reduced morbidity, mortality, and HIV transmission (2-4). Further, approximately half of persons enrolled in non-ART care that included monitoring for HIV disease progression (i.e., in pre-ART care) were lost to follow-up before becoming ART-eligible (5). India, the country with the third largest number of persons with HIV infection in the world (2.1 million), adopted the Treat All policy on April 28, 2017. This report describes implementation of Treat All during May 2017-June 2018, by India's National AIDS Control Organization (NACO) and partners, by facilitating ART initiation among persons previously in pre-ART care at 46 ART centers supported by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR)* in six districts in the states of Maharashtra and Andhra Pradesh. Partners supported these 46 ART centers in identifying and attempting to contact persons who were enrolled in pre-ART care during January 2014-April 2017, and educating those reached about Treat All. ART center-based records were used to monitor implementation indicators, including ART initiation. A total of 9,898 (39.6%) of 25,007 persons previously enrolled in pre-ART care initiated ART; among these 9,898 persons, 6,315 (63.8%) initiated ART after being reached during May 2017-June 2018, including 1,635 (16.5%) who had been lost to follow-up before ART initiation. NACO scaled up efforts nationwide to build ART centers' capacity to implement Treat All. Active tracking and tracing of persons with HIV infection enrolled in care but not on ART, combined with education about the benefits of early HIV treatment, can facilitate ART initiation.