In Vivo MRI Cell Tracking: Clinical Studies

• Published in: American journal of roentgenology (1976) Vol. 193; no. 2; pp. 314 - 325
• Main Author: Bulte, Jeff W. M
• Format: Journal Article
• Language: English
• Published: Reston, VA Am Roentgen Ray Soc 01.08.2009; American Roentgen Ray Society
• Subjects: Adult; Aged; Animals; Biological and medical sciences; Cancer Vaccines; Cell Movement; Cell Transplantation - pathology; Contrast Media; Dendritic Cells - cytology; Female; Ferric Compounds; Humans; Immunotherapy - methods; Investigative techniques, diagnostic techniques (general aspects); Lymphatic Metastasis - pathology; Magnetic Resonance Imaging - methods; Male; Medical sciences; Melanoma - pathology; Melanoma - secondary; Melanoma - therapy; Mice; Skin Neoplasms - pathology; Skin Neoplasms - therapy; Staining and Labeling - methods; Stem Cell Transplantation; Stem Cells - cytology; Swine; Radiology; In vivo; Nuclear medicine; Symptomatology; Medical imagery; Nuclear magnetic resonance imaging
• ISSN: 0361-803X; 1546-3141
• DOI: 10.2214/AJR.09.3107

The purpose of this review is to describe the principles of MRI cell tracking with superparamagnetic iron oxides and the four clinical trials that have been performed. Clinical MRI cell tracking is likely to become an important tool at the bedside once (stem) cell therapy becomes mainstream. The most prominent role of this technique probably will be verification of accurate cell delivery with MRI-guided injection, in which interventional radiologists will play a role in the near future. All clinical studies described as of this writing have been performed outside the United States.