Investigation of the Inhibitory Effect of Simvastatin on the Metabolism of Lidocaine Both in vitro and in vivo

• Published in: Drug design, development and therapy Vol. 14; pp. 1739 - 1747
• Main Authors: Wang, Ying, Ou-Yang, Qiu-Geng, Huang, Wan-Li, Huang, Huan-le, Zhuang, Xin-Lei, Lin, Qian-Meng, Zeng, Da-Li
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Dove; Dove Medical Press
• Subjects: Animals; Anti-Arrhythmia Agents - metabolism; Antilipemic agents; Bupivacaine; Cytochrome P-450; Dose-Response Relationship, Drug; drug-drug interaction; Humans; in vitro model; Investigations; Kinetics; Lidocaine; Lidocaine - metabolism; Metabolites; Microsomes, Liver - chemistry; Microsomes, Liver - metabolism; Molecular Structure; Original Research; pharmacokinetics; Rats; Simvastatin; Simvastatin - pharmacology; Structure-Activity Relationship; China; pharmacokinetics; simvastatin; in vitro model; drug–drug interaction; lidocaine
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S241022

Lidocaine has cardiovascular and neurologic toxicity, which is dose-dependent. Due to CYP3A4-involved metabolism, lidocaine may be prone to drug-drug interactions. Given statins have the possibility of combination with lidocaine in the clinic, we established in vitro models to assess the effect of statins on the metabolism of lidocaine. Further pharmacokinetic alterations of lidocaine and its main metabolite, monoethylglycinexylidide in rats influenced by simvastatin, were investigated. In vitro study revealed that simvastatin, among the statins, had the most significant inhibitory effect on lidocaine metabolism with IC of 39.31 µM, 50 µM and 15.77 µM for RLM, HLM and CYP3A4.1, respectively. Consistent with in vitro results, lidocaine concomitantly used with simvastatin in rats was associated with 1.2-fold AUC , 1.2-fold AUC , and 20%-decreased clearance for lidocaine, and 1.4-fold C for MEGX compared with lidocaine alone. Collectively, these results implied that simvastatin could evidently inhibit the metabolism of lidocaine both in vivo and in vitro. Accordingly, more attention and necessary therapeutic drug monitoring should be paid to patients with the concomitant coadministration of lidocaine and simvastatin so as to avoid unexpected toxicity.