Effects of a Milk-Based Meal Replacement Program on Weight and Metabolic Characteristics in Adults with Severe Obesity

• Published in: Diabetes, metabolic syndrome and obesity Vol. 13; pp. 197 - 205
• Main Authors: Rafey, Mohammed F, Murphy, Conor F, Abdalgwad, Razk, Kilkelly, Katriona, Griffin, Helena, Beatty, Niamh, O'Shea, Paula M, Collins, Chris, McGrath, Robert, Hynes, Mary, Davenport, Colin, O'Donnell, Martin, Finucane, Francis M
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Dove; Dove Medical Press
• Subjects: Body weight; Diabetics; Dietary supplements; Glycosylated hemoglobin; Hemoglobins; hypocaloric diet; Hypoglycemic agents; lifestyle modifications; Medical research; Milk; Nurses; obesity treatment; Original Research; Physicians; Type 2 diabetes; Weight loss; Weight loss maintenance; Ireland; milk; obesity treatment; type 2 diabetes; lifestyle modification; hypocaloric diet
• ISSN: 1178-7007; 1178-7007
• DOI: 10.2147/DMSO.S226327

Low energy meal replacement regimens can induce short-term weight loss in patients with severe obesity, but usually require specially formulated dietary supplements. We sought to determine the effects of a milk-based meal replacement program on anthropometric and metabolic characteristics in adults with severe obesity. We conducted a retrospective cohort study of patients attending our hospital-based bariatric medicine service who completed a 24-week program consisting of eight weeks of milk-based meal replacement followed by weight stabilisation and maintenance phases. Patients were seen fortnightly by the bariatric physician, nurse and dietitian. We assessed changes in anthropometric and metabolic outcomes in completers at 0, 8, 16 and 24 weeks. Of 105 program completers available for follow-up, 53.3% were female. Mean age was 51.1±11.2 years. Body weight decreased from 144.0±27.6 kg at baseline to 121.1±25.0 kg at 24 weeks ( <0.001), a mean total body weight loss of 15.9±6.0%, with a reduction in body mass index from 50.6±8.0 to 42.6±7.6 kg m ( <0.001). In patients with diabetes, haemoglobin A1c decreased from 66.3±13.0 to 48.3±13.5 mmol/mol ( <0.001) and diabetes medication use decreased significantly. There were significant improvements also in lipid profiles and reductions in antihypertensive medication use. These preliminary findings suggest that completion of a 24-week milk-based meal replacement program has large effects on important outcomes in adults with severe obesity. However, attrition was high. Prospective assessment of the efficacy, safety, durability and cost-effectiveness of this intervention seems warranted.