Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree

• Published in: Scientific reports Vol. 7; no. 1; p. 45502
• Main Authors: Uemura, Hirokazu, Ghaibeh, A. Ammar, Katsuura-Kamano, Sakurako, Yamaguchi, Miwa, Bahari, Tirani, Ishizu, Masashi, Moriguchi, Hiroki, Arisawa, Kokichi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.03.2017; Nature Publishing Group
• Subjects: 692/499; 692/699; Adult; Aged; Algorithms; Biomarkers - blood; Body mass; Body Mass Index; C-reactive protein; C-Reactive Protein - metabolism; Cross-Sectional Studies; Data mining; Data processing; Decision Trees; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Female; Genetics; Health risk assessment; Humanities and Social Sciences; Humans; Inflammation; Inflammation - blood; Inflammation - metabolism; Male; Middle Aged; multidisciplinary; Prevalence; Prospective Studies; Science; Studies
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/srep45502

To investigate unknown patterns associated with type 2 diabetes in the Japanese population, we first used an alternating decision tree (ADTree) algorithm, a powerful classification algorithm from data mining, for the data from 1,102 subjects aged 35–69 years. On the basis of the investigated patterns, we then evaluated the associations of serum high-sensitivity C-reactive protein (hs-CRP) as a biomarker of systemic inflammation and family history of diabetes (negative, positive or unknown) with the prevalence of type 2 diabetes because their detailed associations have been scarcely reported. Elevated serum hs-CRP levels were proportionally associated with the increased prevalence of type 2 diabetes after adjusting for probable covariates, including body mass index and family history of diabetes ( P for trend = 0.016). Stratified analyses revealed that elevated serum hs-CRP levels were proportionally associated with increased prevalence of diabetes in subjects without a family history of diabetes ( P for trend = 0.020) but not in those with a family history or with an unknown family history of diabetes. Our study demonstrates that systemic inflammation was proportionally associated with increased prevalence of type 2 diabetes even after adjusting for body mass index, especially in subjects without a family history of diabetes.