Reassessing the mechanics of parasite motility and host-cell invasion

The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. This rapidity is achieved via a divergent actomyosin...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 214; no. 5; pp. 507 - 515
Main Authors Tardieux, Isabelle, Baum, Jake
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 29.08.2016
The Rockefeller University Press
Subjects
Animals
Bacteria
Cell Adhesion
Cell adhesion & migration
Cell Movement
Cell Shape
Host-Parasite Interactions
Humans
Life Sciences
Malaria
Models, Biological
Motility
Parasites
Parasites - cytology
Parasitic protozoa
Plasmodium
Reviews
Toxoplasma
Vector-borne diseases
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Summary:The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and Toxoplasma, achieve remarkable speeds of directional cell movement. This rapidity is achieved via a divergent actomyosin motor system, housed within a narrow compartment that lies underneath the length of the parasite plasma membrane. How this motor functions at a mechanistic level during motility and host cell invasion is a matter of debate. Here, we integrate old and new insights toward refining the current model for the function of this motor with the aim of revitalizing interest in the mechanics of how these deadly pathogens move.
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ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.201605100