Phenolic Profiles and Bioactivities of Ten Original Lineage Beans in Thailand

• Published in: Foods Vol. 11; no. 23; p. 3905
• Main Authors: Chupeerach, Chaowanee, Temviriyanukul, Piya, Thangsiri, Sirinapa, Inthachat, Woorawee, Sahasakul, Yuraporn, Aursalung, Amornrat, Wongchang, Pitthaya, Sangkasa-Ad, Parichart, Wongpia, Aphinya, Polpanit, Auytin, Nuchuchua, Onanong, Suttisansanee, Uthaiwan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: Acetylcholinesterase; Agriculture; Alzheimer's disease; Beans; Bioactive compounds; Biological activity; Chemical industry; Chemical properties; Chromatography; Cultivars; Daidzein; Dipeptidyl-peptidase IV; enzyme inhibition; Enzymes; Fatalities; Flavonoids; Food research; Food science; Glucosidase; Glycine; Glycine max; Health aspects; Inhibition; Isoflavones; Kidney beans; Legumes; Low income groups; Mass spectrometry; Mimosaceae; Peptidase; Peptidases; Phaseolus lunatus; Phaseolus vulgaris; Phenolic compounds; Phenols; Phytochemicals; Plant breeding; R&D; Research & development; Scientific imaging; Secretase; Soybeans; Vegetables; Vigna; Vigna angularis; Vigna mungo; Vigna radiata; Vigna umbellata; α-Amylase; α-Glucosidase; Thailand; United States > US; China; Japan; Rwanda; Germany; Bangkok Thailand; Phaseolus lunatus; Vigna angularis; enzyme inhibition; isoflavones; Vigna radiata; Glycine max; Vigna umbellata; Vigna mungo
• ISSN: 2304-8158; 2304-8158
• DOI: 10.3390/foods11233905

Legumes and pulses are important food components with various phytochemicals and health benefits. However, the health-related bioactivities of some underutilized species remain uninvestigated. To breed a new bean lineage with particular health-related properties, this study investigated phenolics (specifically, isoflavones) and the in vitro inhibitory activities of the enzyme relevant to some non-communicable diseases in underutilized cultivars of (lima beans), compared to the commonly consumed (red kidney bean) and beans in the and genera. The results indicated that soybeans in the genus contained the highest isoflavone contents, especially glycitein (1825-2633 mg/100 g bean) and daidzein (1153-6471 mg/100 g bean), leading to potentially higher enzyme inhibitory activities (25-26% inhibition against α-amylase, 54-60% inhibition against α-glucosidase, 42-46% inhibition against dipeptidyl peptidase IV, 12-19% inhibition against acetylcholinesterase and 20-23% inhibition against butyrylcholinesterase) than those from other genera. Interestingly, lima beans with low isoflavone content (up to 2 mg/100 g bean) still possessed high inhibitory activities against lipase (12-21% inhibition) and β-secretase (50-58% inhibition), suggesting that bioactive compounds other than the isoflavones might be responsible for these activities. Isoflavone contents and enzyme inhibitory activities in beans were diverse, depending on the particular cultivars. The information gained from this study can be used for further investigation of bioactive components and in-depth health properties, as well as for future breeding of a new lineage of bean with specific health potentials.